Patrice Mimche Lab
The mission of the Mimche laboratory research program is to perform innovative and cutting-edge research aimed at deciphering the biological processes that promote pathological tissue inflammation and fibrosis. Human fibrotic diseases are a major socioeconomic burden on modern societies and account for up to 45% of deaths in the developed world. My group is currently focused on elucidating the role of the axonal guidance cue Eph/Ephrin system in tissue inflammation and fibrogenesis across various organs including the liver, skin, lung, heart, and kidney. To achieve this goal, we utilize cutting edge molecular biology techniques, genetic manipulation of mice, animal modeling of disease, and translational studies in humans. Our ultimate goal is to develop therapy targeting this cell signaling system for the treatment of fibrotic diseases.